Read online or download a free book: Effect Of Leptin On Experimental Liver Injury Induced By Ethanol
Publisher: LAP LAMBERT Academic Publishing (1 Aug. 2013)
By: Balasubramaniyan Vairappan (Author), Nalini Namasivayam (Author)
Book format: pdf doc docx mobi djvu epub ibooks (*An electronic version of a printed book that can be read on a computer or handheld device designed specifically for this purpose.)
Liver disease is among the top ten killer diseases in India, affecting people in all age groups and causing millions of deaths on an annual basis Worldwide. Liver damage in humans is induced by numerous insults including alcohol abuse, when persistent, leads to development of liver cirrhosis, eventually it causes death in these patients. Obesity is frequently associated with steatohepatitis, a pattern of liver injury that often progresses to cirrhosis in alcoholic individuals. Leptin, an anti-obesity hormone exerts potent modulatory properties both in vivo and in vitro. In this project, leptin treatment to ethanol fed mice, significantly lowered body weight, plasma and tissue lipids, oxidative stress, cytokine response, fibrosis, apoptosis and altered fatty acid composition. In addition, leptin treatment showed significantly increased antioxidant status and decreased oxidative stress, cytokines, and apoptosis in ethanol-exposed HepG2 and mouse hepatocellular carcinoma (HCC) cell lines. The above results were consistent with the liver histopathological observations, confirming the potential beneficial effect of leptin on alcoholic liver disease (ALD).
*Report a Broken Link
Sherlock Holmes: From Victorian Sleuth to Modern Hero Nowhere to Run (Joe Pickett Novels)